Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GOT1 | P17174 | 8/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324731 | 0.81 | TDO2 (0.55) | ALDH1A1NPSR1GAAMAPTSMN1; SMN2 | |
| SCHEMBL4306478 | 0.80 | ADRB1 (0.69) | ADRB1HTR6DRD2DRD4DRD3 | |
| SCHEMBL2953569 | 0.79 | GAA (0.59) | ADRB1HTR6DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL5698349 | 0.79 | ADRB1 (0.67) | ADRB1HTR6DRD2DRD4DRD3 | |
| SCHEMBL20581870 | 0.78 | ADRB1 (0.75) | ADRB1HTR6DRD2DRD4DRD3 | |
| SCHEMBL17738539 | 0.78 | ALDH1A1 (0.52) | ALDH1A1NPSR1SMN1; SMN2KMT2AHTT | |
| SCHEMBL18324876 | 0.77 | TDO2 (0.51) | ALDH1A1NPSR1GAAMAPTSMN1; SMN2 | |
| SCHEMBL30160211 | 0.77 | ADRB1 (0.73) | ADRB1HTR6DRD2DRD4DRD3 | |
| SCHEMBL8861994 | 0.77 | ADRB1 (0.73) | ADRB1HTR6DRD2DRD4DRD3 | |
| SCHEMBL23102103 | 0.77 | DRD2 (0.68) | ADRB1HTR6DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576559-B1 | INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| US-8536172-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536172-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-09-17 | — | — | US | disclosed |
| EP-2576559-A1 | INHIBITORS OF JNK | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| CN-102918046-A | Inhibitors of jnk | HOFFMANN LA ROCHE | 2013-02-06 | — | — | CN | disclosed |
| WO-2011151357-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110034470-A1 | Inhibitors of JNK | GONG LEYI | 2011-02-10 | — | — | US | disclosed |
| US-20110034470-A1 | Inhibitors of JNK | GONG LEYI | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034470-A1 | Inhibitors of JNK | MAPK1, MAP3K6, MAP3K3 | ADRB1 1721/4885HTR6 2347/4885ALDH1A1 4551/4885 |
| US-20110301170-A1 | Inhibitors of JNK | MAPK6, MAP3K6, MAPK1 | ADRB1 1630/4885HTR6 1423/4885ALDH1A1 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.