Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862139 | 0.78 | KMT2A (0.54) | NPSR1KDM4EMAPTTSHRHTT | |
| SCHEMBL6864124 | 0.72 | HSP90AA1 (0.59) | KDM4EMAPTTSHRHTTSMN1; SMN2 | |
| (4-Chlorophenyl)(Morpholino)Methanone SCHEMBL27532341 | 0.72 | PHGDH (0.69) | KDM4EMAPTTSHRHTTSMN1; SMN2 | |
| SCHEMBL20678975 | 0.70 | ALDH1A1 (0.50) | MAPTTSHRSMN1; SMN2LMNAPKM | |
| SCHEMBL5584823 | 0.70 | RAB9A (0.43) | NPSR1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL6780707 | 0.70 | KDM4E (0.61) | KDM4EHTTSMN1; SMN2LMNARAB9A | |
| SCHEMBL5584944 | 0.69 | RIPK1 (0.56) | KDM4EMAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL5584301 | 0.68 | HTR1D (0.50) | NPSR1MAPTHTTSMN1; SMN2RAB9A | |
| SCHEMBL5584304 | 0.68 | HTR1D (0.50) | NPSR1MAPTHTTSMN1; SMN2RAB9A | |
| SCHEMBL23021686 | 0.68 | KDM4E (0.61) | KDM4ERORCMAPTTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |