Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463443 | 0.86 | PDE4A (0.42) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL6865485 | 0.86 | YTHDC1 (0.47) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL3145916 | 0.82 | YTHDC1 (0.51) | CDK1CTSLCTSBPDE5AMCHR1 | |
| SCHEMBL3131755 | 0.82 | YTHDC1 (0.51) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL3582728 | 0.79 | PDE4A (0.51) | YTHDC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3141403 | 0.77 | YTHDC1 (0.51) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL3130747 | 0.74 | CTSL (0.58) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL3133524 | 0.72 | CCNE1 (0.53) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL3137222 | 0.72 | CTSL (0.59) | CDK1CCNE1CDK2CTSLCTSB | |
| SCHEMBL6863830 | 0.72 | PDE5A (0.55) | CDK1CCNE1CDK2CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383767-A1 | TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2004-01-28 | — | — | EP | claimed |
| WO-2002098878-A1 | TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2002-12-12 | — | — | WO | claimed |