Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27142364 | 0.85 | TRPV4 (0.56) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL25450396 | 0.83 | TRPV4 (0.54) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL22980481 | 0.82 | TRPV4 (0.53) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL6862266 | 0.79 | TRPV4 (0.50) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL14339474 | 0.78 | KDM4E (0.50) | ALDH1A1LMNAPOLBKMT2AMCOLN3 | |
| SCHEMBL3746673 | 0.76 | ALDH1A1 (0.56) | TRPV4ALDH1A1LMNAKMT2ACYP1A2 | |
| SCHEMBL29785793 | 0.76 | TRPV4 (0.55) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL2494766 | 0.76 | TRPV4 (0.55) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL750886 | 0.74 | TRPV4 (0.73) | TRPV4ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL38243330 | 0.74 | TRPV4 (0.73) | TRPV4ALDH1A1LMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6432656-B1 | Calcilytic compounds | NPS PHARMACEUTICALS, INC. | 2002-08-13 | — | — | US | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| US-4681950-A | PHOTOSENSITIZERS | CIBA-GEIGY CORPORATION (US) | 1987-07-21 | — | — | US | disclosed |
| US-4672138-A | INTERMEDIATES FOR BENZO (B) THIOPHENES; HYPOTENSIVE AGENTS, DIURETICS | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-09 | — | — | US | disclosed |
| US-4585876-A | PHOTOSENSITIZERS | CIBA-GEIGY CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| EP-0050326-B1 | BENZO(B)THIOPHENES | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-01-29 | — | — | EP | disclosed |
| EP-0155981-A2 | Derivatives of alkoxythiophenol; alkoxyphenolthio carbamates | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4537976-A | Benzo[b]thiophenes | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-08-27 | — | — | US | disclosed |
| US-4528399-A | Benzo[b]thiophenes intermediates | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4436748-A | HYPOTENSIVES, DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-03-13 | — | — | US | disclosed |
| US-4389416-A | DIURETICS | ABBOTT LABORATORIES (US) | 1983-06-21 | — | — | US | disclosed |
| EP-0050326-A2 | Benzo(b)thiophenes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-04-28 | — | — | EP | disclosed |