Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785793 | 1.00 | TRPV4 (0.55) | TRPV4MAPTTDP1ALDH1A1POLB | |
| SCHEMBL2495168 | 0.85 | TRPV4 (0.45) | TRPV4MAPTALDH1A1POLBKMT2A | |
| SCHEMBL8187498 | 0.85 | TRPV4 (0.51) | TRPV4MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL6176193 | 0.83 | TRPV4 (0.50) | TRPV4MAPTTDP1ALDH1A1POLB | |
| SCHEMBL1713241 | 0.82 | TRPV4 (0.49) | TRPV4RAB9ASMN1; SMN2NPC1NPSR1 | |
| SCHEMBL29969255 | 0.82 | TRPV4 (0.49) | TRPV4RAB9ASMN1; SMN2NPC1NPSR1 | |
| SCHEMBL11565779 | 0.82 | ALDH1A1 (0.44) | TRPV4ALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL4207227 | 0.80 | CA2 (0.49) | MAPTTDP1ALDH1A1POLBKMT2A | |
| SCHEMBL3746673 | 0.80 | ALDH1A1 (0.56) | TRPV4MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL7269471 | 0.80 | MAPT (0.46) | TRPV4MAPTTDP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111943889-B | Bis-aryl amine compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111943889-A | Bis-aryl amine compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2020-11-17 | — | — | CN | disclosed |
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
| US-6583161-B1 | Regulating low-density lipoprotein (LDL) receptor expression and inhibiting abnormal cell proliferation | TULARIK INC. | 2003-06-24 | — | — | US | disclosed |
| US-6191170-B1 | ANTICHOLESTEROL AGENTS; SKIN DISORDERS; ANTICANCER AGENTS | TULARIK INC. | 2001-02-20 | — | — | US | disclosed |
| WO-1999036391-A1 | BENZENESULFONAMIDES AND BENZAMIDES AS THERAPEUTIC AGENTS | TULARIK INC. (US) | 1999-07-22 | — | — | WO | disclosed |
| EP-0167245-B1 | ANTI-ARRHYTHMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-16 | — | — | EP | disclosed |
| US-4587360-A | Anti-arrhythmic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0167245-A1 | Anti-arrhythmic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | TRPV4 355/4885MAPT 672/4885TDP1 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.