Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247679 | 0.82 | NPC1 (0.49) | TRPV4EPAS1LMNAMAPTCYP2C9 | |
| SCHEMBL6864310 | 0.79 | TRPV4 (0.59) | TRPV4LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL6862282 | 0.78 | ALDH1A1 (0.64) | ALDH1A1POLBMCOLN3MAPK1L3MBTL1 | |
| SCHEMBL2928578 | 0.74 | TRPV4 (0.42) | TRPV4LMNAMAPTCYP2C9ALDH1A1 | |
| SCHEMBL6865452 | 0.73 | KMT2A (0.49) | LMNAMAPTALDH1A1POLBNPC1 | |
| SCHEMBL27142364 | 0.73 | TRPV4 (0.56) | TRPV4LMNAMAPTCYP2C9ALDH1A1 | |
| SCHEMBL1941882 | 0.72 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL19682479 | 0.72 | TRPV4 (0.70) | TRPV4 | |
| SCHEMBL31124656 | 0.72 | MAPT (0.53) | LMNAMAPTCYP2C9ALDH1A1NPC1 | |
| SCHEMBL7064467 | 0.72 | MAPT (0.53) | LMNAMAPTCYP2C9ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |