Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL7719305 | 0.92 | KMT2A (0.50) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL9397484 | 0.83 | KMT2A (0.47) | KMT2AMEN1KDM4EMAPTLMNA | |
| Tryptophan SCHEMBL8412516 | 0.79 | GHSR (0.33) | — | |
| Tyrosine SCHEMBL6135474 | 0.77 | KMT2A (0.50) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL8503631 | 0.76 | ITGB3 (0.32) | — | |
| SCHEMBL7356307 | 0.76 | KDM4E (0.63) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL3442895 | 0.76 | KDM4E (0.57) | KMT2AMEN1KDM4EMAPTLMNA | |
| D-Tryptophan SCHEMBL2221762 | 0.76 | MEN1 (0.53) | KMT2AMEN1KDM4EMAPTLMNA | |
| Tryptophan SCHEMBL17294093 | 0.75 | KMT2A (0.68) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL6032937 | 0.75 | KMT2A (0.71) | KMT2AMEN1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020022229-A1 | Detecting genetic disorder; obtain sample, detect bone morphogenic protein mutation, the presence of mutation indicates genetic disorder | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2002-02-21 | — | — | US | claimed |
| US-6800440-B2 | DETECTING GENETIC DISORDER; OBTAIN SAMPLE, DETECT BONE MORPHOGENIC PROTEIN MUTATION, THE PRESENCE OF MUTATION INDICATES GENETIC DISORDER | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2004-10-05 | — | — | US | disclosed |
| US-20020022229-A1 | Detecting genetic disorder; obtain sample, detect bone morphogenic protein mutation, the presence of mutation indicates genetic disorder | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2002-02-21 | — | — | US | disclosed |
| WO-2002004684-A1 | ROLE OF PPH1 GENE IN PULMONARY HYPERTENSION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2002-01-17 | — | — | WO | disclosed |