SCHEMBL6865181

SCHEMBL6865181

CON(C)C(=O)CN1CCN(Cc2cccc(CF)c2)CC1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.44
DRD4 P21917 1/20 0.44
ALDH1A1 P00352 8/20 0.43
KDM4E B2RXH2 5/20 0.43
HTT P42858 2/20 0.43
SIGMAR1 Q99720 1/20 0.42
TSHR P16473 2/20 0.42
GAA P10253 1/20 0.42
MEN1 O00255 3/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPT P10636 1/20 0.41
ATM Q13315 1/20 0.41
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
ALOX15 P16050 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6864373 0.88 ALDH1A1 (0.56) KMT2AALDH1A1KDM4EHTTMEN1
SCHEMBL6864374 0.85 ALDH1A1 (0.54) KMT2AALDH1A1KDM4EHTTSIGMAR1
SCHEMBL6858172 0.84 DRD4 (0.59) KMT2ADRD4ALDH1A1SIGMAR1MEN1
SCHEMBL7109692 0.84 ALDH1A1 (0.48) KMT2ADRD4ALDH1A1KDM4EHTT
SCHEMBL6864728 0.82 FAAH (0.53) KMT2ADRD4ALDH1A1MEN1HSD17B10
SCHEMBL6863601 0.82 ALDH1A1 (0.59) KMT2AALDH1A1KDM4EHTTSIGMAR1
SCHEMBL6865538 0.78 ALDH1A1 (0.47) KMT2AALDH1A1KDM4EHTTTSHR
SCHEMBL15830278 0.76 ALDH1A1 (0.60) KMT2ADRD4ALDH1A1KDM4EHTT
SCHEMBL17072673 0.76 DRD4 (0.51) KMT2ADRD4ALDH1A1KDM4EHTT
SCHEMBL6864901 0.76 ALDH1A1 (0.50) KMT2AALDH1A1KDM4ETSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817489-A BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-10-06 US claimed
US-6800444-B1 USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS/INTERMEDIATES ISIS PHARMACEUTICALS, INC. 2004-10-05 US disclosed
US-6150129-A USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS AND AS INTERMEDIATES FOR PREPARATION OF OTHER PHARMACEUTICAL AGENTS ISIS PHARMACEUTICALS, INC. (US) 2000-11-21 US disclosed
US-5922872-A BACTERICIDES AND DRUGS ISIS PHARMACEUTICALS, INC. (US) 1999-07-13 US disclosed
US-5817489-A BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-10-06 US disclosed
US-5798360-A ANTIBACTERIAL AGENTS ISIS PHARMACEUTICALS, INC. (US) 1998-08-25 US disclosed
US-5780241-A ALTERING ELECTROCHEMICAL PROPERTIES BY DECYCLIZATION ISIS PHARMACEUTICALS, INC. (US) 1998-07-14 US disclosed
US-5731438-A BACTERICIDES; DRUGS ISIS PHARMACEUTICALS, INC. (US) 1998-03-24 US disclosed
WO-1998005332-A1 NOVEL HETEROCYCLE COMPOSITIONS ISIS PHARMACEUTICALS, INC. (US) 1998-02-12 WO disclosed