SCHEMBL6864374

SCHEMBL6864374

CON(C)C(=O)CN1CCN(Cc2cccc(C(F)(F)F)c2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.54
KDM4E B2RXH2 3/20 0.54
GAA P10253 3/20 0.54
LMNA P02545 3/20 0.53
FAAH O00519 2/20 0.53
OPRL1 P41146 1/20 0.49
SIGMAR1 Q99720 2/20 0.49
CACNA1G O43497 1/20 0.48
HTT P42858 1/20 0.48
KMT2A Q03164 1/20 0.48
KCNH2 Q12809 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
S1PR1 P21453 1/20 0.47
GRK5 P34947 1/20 0.47
CDK8 P49336 1/20 0.47
S1PR5 Q9H228 1/20 0.47
UBE2M P61081 1/20 0.46
DCUN1D1 Q96GG9 1/20 0.46
TP53 P04637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6865181 0.85 KMT2A (0.44) ALDH1A1KDM4EGAASIGMAR1HTT
SCHEMBL6864373 0.84 ALDH1A1 (0.56) ALDH1A1KDM4EFAAHHTTKMT2A
SCHEMBL1735001 0.84 LMNA (0.58) ALDH1A1KDM4EGAALMNAHTT
SCHEMBL6858172 0.81 DRD4 (0.59) ALDH1A1LMNASIGMAR1KMT2ASMN1; SMN2
SCHEMBL7109692 0.81 ALDH1A1 (0.48) ALDH1A1KDM4ELMNAHTTKMT2A
SCHEMBL6863601 0.80 ALDH1A1 (0.59) ALDH1A1KDM4ELMNAFAAHSIGMAR1
SCHEMBL6864728 0.80 FAAH (0.53) ALDH1A1FAAHKMT2A
SCHEMBL6861962 0.79 KDM4E (0.63) ALDH1A1KDM4EGAALMNAFAAH
SCHEMBL4087349 0.79 MEN1 (0.50) ALDH1A1KDM4EHTTKMT2ASMN1; SMN2
SCHEMBL6865563 0.77 FAAH (0.61) ALDH1A1KDM4EGAALMNAFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817489-A BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-10-06 US claimed
US-6800444-B1 USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS/INTERMEDIATES ISIS PHARMACEUTICALS, INC. 2004-10-05 US disclosed
US-6150129-A USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS AND AS INTERMEDIATES FOR PREPARATION OF OTHER PHARMACEUTICAL AGENTS ISIS PHARMACEUTICALS, INC. (US) 2000-11-21 US disclosed
US-5922872-A BACTERICIDES AND DRUGS ISIS PHARMACEUTICALS, INC. (US) 1999-07-13 US disclosed
US-5817489-A BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-10-06 US disclosed
US-5798360-A ANTIBACTERIAL AGENTS ISIS PHARMACEUTICALS, INC. (US) 1998-08-25 US disclosed
US-5780241-A ALTERING ELECTROCHEMICAL PROPERTIES BY DECYCLIZATION ISIS PHARMACEUTICALS, INC. (US) 1998-07-14 US disclosed
WO-1998020349-A1 COMPLEX CHEMICAL LIBRARIES ISIS PHARMACEUTICALS, INC. (US) 1998-05-14 WO disclosed
US-5731438-A BACTERICIDES; DRUGS ISIS PHARMACEUTICALS, INC. (US) 1998-03-24 US disclosed
WO-1998005332-A1 NOVEL HETEROCYCLE COMPOSITIONS ISIS PHARMACEUTICALS, INC. (US) 1998-02-12 WO disclosed