Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.37 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 7/20 | 0.34 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.34 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237774 | 0.89 | EHMT2 (0.45) | EHMT2EHMT1SLC2A1SPIN1PIK3CA | |
| SCHEMBL5421592 | 0.79 | EHMT2 (0.39) | EHMT2EHMT1SLC2A1SPIN1PIK3CA | |
| SCHEMBL6234157 | 0.79 | NMT1 (0.37) | EHMT2EHMT1HTR2AJAK2 | |
| SCHEMBL6919803 | 0.79 | EHMT2 (0.45) | EHMT2EHMT1SLC2A1SPIN1KMT5A | |
| SCHEMBL6863012 | 0.78 | SLC6A2 (0.34) | EHMT2EHMT1SLC2A1SPIN1PIK3CA | |
| SCHEMBL6430010 | 0.78 | EHMT2 (0.37) | EHMT2EHMT1SPIN1HTR2A | |
| Citric Acid SCHEMBL4829665 | 0.77 | EHMT2 (0.41) | EHMT2EHMT1 | |
| SCHEMBL6921934 | 0.77 | EHMT2 (0.38) | EHMT2EHMT1SLC2A1SPIN1PIK3CA | |
| Citric Acid SCHEMBL6016965 | 0.76 | EHMT2 (0.43) | EHMT2EHMT1 | |
| SCHEMBL6818739 | 0.75 | SMN1; SMN2 (0.46) | EHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077648-A1 | Methods and compositions of novel triazine compounds | DR. REDDY'S LABORATORIES LTD. (IN) | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077648-A1 | Methods and compositions of novel triazine compounds | AREG, TGFB1, PTGIS | JAK2 114/4885EHMT2 2905/4885EHMT1 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.