Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | IDUA | P35475 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 2/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9560502 | 0.84 | IDUA (0.41) | KDM4ETSHRHTTIDUAHSD17B10 | |
| SCHEMBL2369309 | 0.81 | — | — | |
| SCHEMBL17032222 | 0.81 | — | — | |
| Succinic Acid SCHEMBL31252535 | 0.76 | LMNA (0.44) | LMNAEGLN1ALKBH5SUCNR1KDM4E | |
| Succinic Acid SCHEMBL7116405 | 0.71 | — | — | |
| SCHEMBL7055465 | 0.69 | IDUA (0.48) | LMNAKDM4EIDUAHSD17B10 | |
| Succinic Acid SCHEMBL829 | 0.67 | — | — | |
| Succinic Acid SCHEMBL4269130 | 0.67 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1KDM4E | |
| Succinic Acid SCHEMBL21867134 | 0.67 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1KDM4E | |
| Succinic Acid SCHEMBL1331200 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1454627-A1 | Alpha-Keto carbonyl calpain inhibitors | MyoContract Ltd. (CH) | 2004-09-08 | — | — | EP | disclosed |