SCHEMBL6865769

SCHEMBL6865769

Cc1c(SCCCN2CCN(Cc3ccncc3)CC2)ccnc1CNc1ncncc1Cl

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM4 P08173 1/20 0.33
CYP2D6 P10635 5/20 0.33
CYP3A4 P08684 4/20 0.33
CYP1A2 P05177 4/20 0.33
LMNA P02545 3/20 0.33
CYP2C19 P33261 3/20 0.33
HIF1A Q16665 2/20 0.33
TSHR P16473 1/20 0.33
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
KDR P35968 1/20 0.31
MAPK1 P28482 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CCR2 P41597 1/20 0.31
LSS P48449 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6869698 0.88 CYP2D6 (0.44) CYP2D6CYP3A4CYP1A2LMNACYP2C19
Hydrochloric Acid SCHEMBL6861864 0.83 KDM4E (0.32) CYP2D6CYP3A4LMNACYP2C19TSHR
SCHEMBL6869025 0.83 CHRM4 (0.36) CHRM4CYP2D6CYP3A4CYP1A2CYP2C19
SCHEMBL6862058 0.82 CYP1A2 (0.34) CHRM4CYP2D6CYP3A4CYP1A2CYP2C19
SCHEMBL6866116 0.81 METAP1 (0.33) CYP2D6CYP3A4LMNACYP2C19TSHR
SCHEMBL7678516 0.78 FAAH (0.42) KDRMEN1KMT2A
SCHEMBL7011518 0.73 KMT2A (0.43) TSHRMEN1KMT2ACCR2
SCHEMBL6861858 0.73 CYP1A2 (0.31) CYP2D6CYP3A4CYP1A2CYP2C19TSHR
SCHEMBL6868402 0.71 GRM2 (0.31)
SCHEMBL6869763 0.71 SMN1; SMN2 (0.39) CYP2D6CYP3A4CYP1A2LMNACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091957-B1 PYRIMIDIN-AMINOMETHYL-PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE CONTROL OF HELICOBACTER BACTERIA ALTANA PHARMA AG (DE) 2004-12-15 EP disclosed
US-6395732-B1 BACTERICIDES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2002-05-28 US disclosed
EP-1091957-A1 PYRIMIDIN-AMINOMETHYL-PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE CONTROL OF HELICOBACTER BACTERIA Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-04-18 EP disclosed
WO-1999061439-A1 PYRIMIDIN-AMINOMETHYL-PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE CONTROL OF HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1999-12-02 WO disclosed