Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | RARG | P13631 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | RXRB | P28702 | 2/20 | 0.32 |
| ▸ | RXRG | P48443 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27521518 | 0.81 | L3MBTL1 (0.40) | LMNAMAPTNPSR1MEN1KMT2A | |
| SCHEMBL4150610 | 0.75 | F2 (0.48) | F2PRSS1TMPRSS15LMNAMAPT | |
| SCHEMBL8430296 | 0.72 | MEN1 (0.47) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8430294 | 0.72 | MEN1 (0.47) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL187458 | 0.68 | MEN1 (0.56) | LMNANPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL186729 | 0.68 | MEN1 (0.56) | LMNANPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL3682708 | 0.68 | MEN1 (0.56) | LMNANPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL4388032 | 0.68 | DAO (0.37) | F2LMNAMAPTNPSR1MEN1 | |
| SCHEMBL4388033 | 0.68 | DAO (0.37) | F2LMNAMAPTNPSR1MEN1 | |
| SCHEMBL11720751 | 0.67 | ALDH1A1 (0.49) | MAPTMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1171861-C | halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors | GD | 2004-10-20 | — | — | CN | disclosed |
| EP-1415982-A1 | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2004-05-06 | — | — | EP | disclosed |
| US-6344483-B1 | Halogenated amidino amino acid deviratives useful as nitric oxide synthase inhibitors | G. D. SEARLE & CO. | 2002-02-05 | — | — | US | disclosed |
| EP-1062201-A2 | HALOGENATED AMIDINO AMINO ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046240-A2 | HALOGENATED AMIDINO AMINO ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1999-09-16 | — | — | WO | disclosed |