Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.52 |
| ▸ | ITGAV | P06756 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687571 | 0.84 | ALDH1A1 (0.50) | ITGB3ITGAVITGA2BSMN1; SMN2KMT2A | |
| SCHEMBL688097 | 0.80 | ITGB1 (0.58) | RAB9ANPC1 | |
| SCHEMBL687813 | 0.80 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPTTP53 | |
| SCHEMBL3141349 | 0.78 | ITGB3 (0.58) | ITGB3ITGAVITGA2BKMT2AMEN1 | |
| SCHEMBL688325 | 0.78 | ALDH1A1 (0.51) | ITGB3ITGAVITGA2BSMN1; SMN2KMT2A | |
| SCHEMBL695420 | 0.78 | MAPT (0.54) | ITGB3ITGA2BSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL688224 | 0.78 | PTGER3 (0.51) | ITGB3ITGAVITGA2BKMT2AMEN1 | |
| SCHEMBL686731 | 0.77 | MAPT (0.55) | SMN1; SMN2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL687428 | 0.77 | PTGER3 (0.56) | ITGB3ITGAVSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL688073 | 0.77 | ALDH1A1 (0.44) | ITGB3ITGAVITGA2BSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |