Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.39 |
| ▸ | HTR2B | P41595 | 5/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878367 | 1.00 | ADAM17 (0.40) | ADAM17EPHX2MCHR1ADRA2AHRH1 | |
| SCHEMBL6872301 | 0.87 | CYP3A4 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6872308 | 0.87 | CYP3A4 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6867305 | 0.86 | MAPT (0.47) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6867296 | 0.86 | MAPT (0.47) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873199 | 0.86 | EPHX1 (0.53) | EPHX2MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6873195 | 0.86 | EPHX1 (0.53) | EPHX2MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL5526046 | 0.83 | MCHR1 (0.58) | EPHX2MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL5526037 | 0.83 | MCHR1 (0.58) | EPHX2MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878265 | 0.83 | ALDH1A1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |