Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867565 | 1.00 | KMT2A (0.44) | KMT2AMEN1CYP3A4CYP2D6MAPT | |
| SCHEMBL6877414 | 0.89 | KMT2A (0.56) | KMT2AMEN1CYP2D6HTTMAPK14 | |
| SCHEMBL6874218 | 0.89 | MCHR1 (0.41) | KMT2AALDH1A1ALOX12HTTMAPK14 | |
| SCHEMBL6877409 | 0.89 | KMT2A (0.56) | KMT2AMEN1CYP2D6HTTMAPK14 | |
| SCHEMBL6874211 | 0.89 | MCHR1 (0.41) | KMT2AALDH1A1ALOX12HTTMAPK14 | |
| SCHEMBL6876029 | 0.87 | LMNA (0.60) | KMT2AMEN1ALDH1A1LMNAALOX12 | |
| SCHEMBL6876015 | 0.87 | LMNA (0.60) | KMT2AMEN1ALDH1A1LMNAALOX12 | |
| SCHEMBL6875325 | 0.86 | ALOX12 (0.44) | MAPTALDH1A1ALOX12MCHR1SMN1; SMN2 | |
| SCHEMBL6875329 | 0.86 | ALOX12 (0.44) | MAPTALDH1A1ALOX12MCHR1SMN1; SMN2 | |
| SCHEMBL6872864 | 0.85 | ALDH1A1 (0.56) | KMT2AMEN1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |