Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876029 | 1.00 | LMNA (0.60) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6878402 | 0.90 | LMNA (0.56) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6878392 | 0.90 | LMNA (0.56) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6877173 | 0.89 | KMT2A (0.46) | LMNAALDH1A1ALOX12SMN1; SMN2KMT2A | |
| SCHEMBL6877186 | 0.89 | KMT2A (0.46) | LMNAALDH1A1ALOX12SMN1; SMN2KMT2A | |
| SCHEMBL6867558 | 0.87 | KMT2A (0.44) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6867565 | 0.87 | KMT2A (0.44) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6876224 | 0.85 | GLA (0.48) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6876213 | 0.85 | GLA (0.48) | LMNAALDH1A1ALOX12SMN1; SMN2THRB | |
| SCHEMBL6872864 | 0.83 | ALDH1A1 (0.56) | LMNAALDH1A1ALOX12SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |