Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873684 | 0.89 | ADORA2A (0.46) | ADORA2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6872164 | 0.86 | ADORA2A (0.59) | ADORA2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6863226 | 0.82 | ADORA2A (0.67) | ADORA2AMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL6863351 | 0.81 | PLAU (0.47) | ADORA2AMEN1KMT2AMAPTPOLB | |
| SCHEMBL6869917 | 0.81 | ADORA2A (0.58) | ADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL6872068 | 0.81 | ADORA2A (0.52) | ADORA2AMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL6871437 | 0.81 | ADORA2A (0.47) | ADORA2AALDH1A1HPGD | |
| SCHEMBL6870566 | 0.80 | ADORA2A (0.45) | ADORA2AMEN1KMT2AMAPTHSD17B2 | |
| SCHEMBL6870537 | 0.80 | ADORA2A (0.62) | ADORA2AHSD17B2HSD17B1 | |
| SCHEMBL6870638 | 0.80 | ADORA2A (0.55) | ADORA2AMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |