Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863086 | 0.89 | PLAU (0.44) | PLAUHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6867499 | 0.87 | KMT2A (0.43) | ALDH1A1CYP2D6HDAC3HDAC1HDAC2 | |
| SCHEMBL6870466 | 0.87 | TP53 (0.47) | HPGDKDM4EALDH1A1HSD17B10CYP2C19 | |
| SCHEMBL6872062 | 0.85 | TP53 (0.47) | HPGDKDM4EALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL6869820 | 0.85 | KDM4E (0.44) | HPGDKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL6870449 | 0.85 | RAB9A (0.45) | PLAUHPGDALDH1A1CYP2C9HDAC3 | |
| SCHEMBL6873157 | 0.84 | HPGDS (0.51) | PLAUHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6871700 | 0.83 | SMN1; SMN2 (0.41) | HPGDKDM4EALDH1A1RXFP1TP53 | |
| SCHEMBL6871437 | 0.81 | ADORA2A (0.47) | HPGDALDH1A1ADORA2A | |
| SCHEMBL6867905 | 0.81 | ADORA2A (0.54) | HPGDALDH1A1HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |