Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868999 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTKMT2AMEN1EPHX1 | |
| SCHEMBL6874444 | 0.92 | BCHE (0.46) | SMN1; SMN2KMT2AMEN1BCHEACHE | |
| SCHEMBL6874440 | 0.92 | BCHE (0.46) | SMN1; SMN2KMT2AMEN1BCHEACHE | |
| SCHEMBL6875779 | 0.88 | LMNA (0.44) | SMN1; SMN2MAPTBCHEACHEALDH1A1 | |
| SCHEMBL6875783 | 0.88 | LMNA (0.44) | SMN1; SMN2MAPTBCHEACHEALDH1A1 | |
| SCHEMBL6880458 | 0.86 | KMT2A (0.46) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL6868868 | 0.86 | KMT2A (0.56) | SMN1; SMN2MAPTKMT2AMEN1ACHE | |
| SCHEMBL6868863 | 0.86 | KMT2A (0.56) | SMN1; SMN2MAPTKMT2AMEN1ACHE | |
| SCHEMBL6869024 | 0.85 | KMT2A (0.58) | SMN1; SMN2MAPTKMT2AMEN1EPHX1 | |
| SCHEMBL6869028 | 0.85 | KMT2A (0.58) | SMN1; SMN2MAPTKMT2AMEN1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |