Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874440 | 1.00 | BCHE (0.46) | BCHEACHEAPPCYP1A2CYP3A4 | |
| SCHEMBL6869003 | 0.92 | SMN1; SMN2 (0.51) | BCHEACHEAPPCYP1A2LMNA | |
| SCHEMBL6868999 | 0.92 | SMN1; SMN2 (0.51) | BCHEACHEAPPCYP1A2LMNA | |
| SCHEMBL6875718 | 0.89 | PKM (0.45) | LMNAPKMHTTSMN1; SMN2HPGD | |
| SCHEMBL6875715 | 0.89 | PKM (0.45) | LMNAPKMHTTSMN1; SMN2HPGD | |
| SCHEMBL6866804 | 0.88 | LMNA (0.60) | BCHEACHELMNAPKMHTT | |
| SCHEMBL6866808 | 0.88 | LMNA (0.60) | BCHEACHELMNAPKMHTT | |
| SCHEMBL6876780 | 0.86 | KMT2A (0.58) | LMNAHPGDMEN1KMT2AADRA2A | |
| SCHEMBL6876785 | 0.86 | KMT2A (0.58) | LMNAHPGDMEN1KMT2AADRA2A | |
| SCHEMBL6460982 | 0.86 | SMN1; SMN2 (0.40) | HTTSMN1; SMN2MEN1KMT2AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |