Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875783 | 1.00 | LMNA (0.44) | LMNAMAPTSMN1; SMN2TP53MCHR1 | |
| SCHEMBL6869003 | 0.88 | SMN1; SMN2 (0.51) | LMNAMAPTSMN1; SMN2ACHEBCHE | |
| SCHEMBL6868999 | 0.88 | SMN1; SMN2 (0.51) | LMNAMAPTSMN1; SMN2ACHEBCHE | |
| SCHEMBL6873448 | 0.84 | MEN1 (0.48) | LMNAMAPTTP53MCHR1ADRA2A | |
| SCHEMBL6873456 | 0.84 | MEN1 (0.48) | LMNAMAPTTP53MCHR1ADRA2A | |
| SCHEMBL6878924 | 0.84 | L3MBTL1 (0.46) | LMNAMAPTTP53MCHR1ADRA2A | |
| SCHEMBL6878919 | 0.84 | L3MBTL1 (0.46) | LMNAMAPTTP53MCHR1ADRA2A | |
| SCHEMBL5523191 | 0.84 | MCHR1 (0.60) | LMNAMCHR1ADRA2AACHEBCHE | |
| SCHEMBL5523189 | 0.84 | MCHR1 (0.60) | LMNAMCHR1ADRA2AACHEBCHE | |
| SCHEMBL6460300 | 0.83 | ALDH1A1 (0.45) | LMNAMAPTSMN1; SMN2TP53MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |