Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875610 | 1.00 | KDM1A (0.46) | KDM1AMAOASMN1; SMN2DPP8DPP7 | |
| SCHEMBL6464818 | 0.89 | SMN1; SMN2 (0.46) | KDM1AMAOASMN1; SMN2DPP8DPP7 | |
| SCHEMBL6878199 | 0.89 | SMN1; SMN2 (0.46) | KDM1AMAOASMN1; SMN2DPP8DPP7 | |
| SCHEMBL6879316 | 0.88 | MAPK8 (0.43) | ACHEBACE1ADRA2AMCHR1MAPK8 | |
| SCHEMBL6879311 | 0.88 | MAPK8 (0.43) | ACHEBACE1ADRA2AMCHR1MAPK8 | |
| SCHEMBL6869183 | 0.86 | KDM1A (0.44) | KDM1AMAOASMN1; SMN2ACHEAPP | |
| SCHEMBL6869175 | 0.86 | KDM1A (0.44) | KDM1AMAOASMN1; SMN2ACHEAPP | |
| SCHEMBL6877433 | 0.82 | ACHE (0.42) | ACHEAPPBCHEKMT2ABACE1 | |
| SCHEMBL6877439 | 0.82 | ACHE (0.42) | ACHEAPPBCHEKMT2ABACE1 | |
| SCHEMBL6867944 | 0.82 | ADRA2A (0.42) | ACHEKMT2ABACE1ADRA2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |