Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 16/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868316 | 0.90 | ADORA2A (0.55) | ADORA2ALMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL6873334 | 0.88 | ADORA2A (0.58) | ADORA2AHPGD | |
| SCHEMBL6870770 | 0.86 | ALDH1A1 (0.41) | ADORA2ALMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL6869607 | 0.85 | ADORA2A (0.52) | ADORA2ALMNAMAPT | |
| SCHEMBL6871493 | 0.85 | ADORA2A (0.66) | ADORA2AHPGDSMN1; SMN2 | |
| SCHEMBL6863192 | 0.82 | ADORA2A (0.71) | ADORA2A | |
| SCHEMBL6867257 | 0.82 | ADORA2A (0.55) | ADORA2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL6869820 | 0.81 | KDM4E (0.44) | LMNAMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL6870936 | 0.80 | ADORA2A (0.64) | ADORA2ALMNA | |
| SCHEMBL6870679 | 0.79 | ADORA2A (0.59) | ADORA2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |