Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870639 | 0.88 | ADORA2A (0.59) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6868316 | 0.86 | ADORA2A (0.55) | ADORA2AMAPTALDH1A1LMNA | |
| SCHEMBL6869252 | 0.85 | ADORA2A (0.57) | ADORA2AMAPTLMNA | |
| SCHEMBL6870770 | 0.85 | ALDH1A1 (0.41) | ADORA2AMAPTALDH1A1LMNA | |
| SCHEMBL6869820 | 0.81 | KDM4E (0.44) | MAPTALDH1A1LMNA | |
| SCHEMBL6870625 | 0.79 | MAPK10 (0.45) | MAPTALDH1A1LMNA | |
| SCHEMBL6867888 | 0.79 | ADORA2A (0.66) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6870605 | 0.79 | ADORA2A (0.58) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL6872375 | 0.78 | ADORA2A (0.60) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL6871219 | 0.78 | ADORA2A (0.56) | ADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |