Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872062 | 0.86 | TP53 (0.47) | KDM4EALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6863351 | 0.85 | PLAU (0.47) | KDM4EHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL6868316 | 0.83 | ADORA2A (0.55) | KDM4EMAPK10SMN1; SMN2HSD17B10PKM | |
| SCHEMBL6869607 | 0.81 | ADORA2A (0.52) | ALDH1A1LMNAMAPT | |
| SCHEMBL6870625 | 0.81 | MAPK10 (0.45) | KDM4EMAPK10SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL6869252 | 0.81 | ADORA2A (0.57) | SMN1; SMN2HSD17B10LMNAMAPTHPGD | |
| SCHEMBL6863086 | 0.80 | PLAU (0.44) | KDM4ESMN1; SMN2HSD17B10ALDH1A1LMNA | |
| SCHEMBL6870770 | 0.79 | ALDH1A1 (0.41) | KDM4EMAPK10SMN1; SMN2HSD17B10PKM | |
| SCHEMBL6868343 | 0.78 | ADORA2A (0.45) | KDM4ESMN1; SMN2RAB9APKMALDH1A1 | |
| SCHEMBL6871700 | 0.78 | SMN1; SMN2 (0.41) | KDM4ESMN1; SMN2RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |