SCHEMBL6870605

SCHEMBL6870605

CCCCNC(=O)c1cc(N)n2nc(-c3ccco3)nc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 13/20 0.58
KMT2A Q03164 3/20 0.54
ALDH1A1 P00352 2/20 0.54
HSD17B10 Q99714 2/20 0.54
KDM4E B2RXH2 1/20 0.54
MEN1 O00255 1/20 0.54
POLB P06746 1/20 0.54
MAPT P10636 1/20 0.54
HPGD P15428 1/20 0.54
ALOX15 P16050 1/20 0.54
CASP1 P29466 1/20 0.54
BLM P54132 1/20 0.54
CASP7 P55210 1/20 0.54
MCL1 Q07820 1/20 0.54
CTDSP1 Q9GZU7 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
ADORA3 P0DMS8 6/20 0.46
F2 P00734 1/20 0.46
ADORA1 P30542 6/20 0.46
ADORA2B P29275 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6870178 0.85 ADORA2A (0.50) ADORA2AKMT2AALDH1A1HSD17B10KDM4E
SCHEMBL6870649 0.84 ADORA2A (0.61) ADORA2A
SCHEMBL6866973 0.83 BACE1 (0.48) KMT2AALDH1A1KDM4EPOLBMAPT
SCHEMBL6871906 0.83 ADORA2A (0.46) ADORA2AKMT2AALDH1A1HSD17B10KDM4E
SCHEMBL6870329 0.83 ADORA2A (0.66) ADORA2AHPGD
SCHEMBL6870530 0.82 ADORA2A (0.43) ADORA2AKMT2AALDH1A1HSD17B10KDM4E
SCHEMBL6872186 0.81 SMN1; SMN2 (0.43) ADORA2AHPGDMCL1
SCHEMBL6870639 0.80 ADORA2A (0.59) ADORA2AALDH1A1ADORA3ADORA1ADORA2B
SCHEMBL6871320 0.80 SMN1; SMN2 (0.43) ADORA2AKMT2AALDH1A1HSD17B10KDM4E
SCHEMBL6869989 0.80 ADORA2A (0.58) ADORA2AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1347974-B1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS HOFFMANN LA ROCHE (CH) 2004-11-03 EP claimed
EP-1347974-A1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2003-10-01 EP claimed
US-6506772-B1 Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. HOFFMANN-LA ROCHE INC. 2003-01-14 US claimed
WO-2002048145-A1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2002-06-20 WO claimed
EP-1347974-B1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS HOFFMANN LA ROCHE (CH) 2004-11-03 EP disclosed
EP-1347974-A1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2003-10-01 EP disclosed
US-6506772-B1 Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. HOFFMANN-LA ROCHE INC. 2003-01-14 US disclosed
WO-2002048145-A1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2002-06-20 WO disclosed