Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873063 | 0.97 | MEN1 (0.44) | ADORA2AMEN1KMT2ALMNAHPGDS | |
| SCHEMBL6869619 | 0.97 | MEN1 (0.44) | ADORA2AMEN1KMT2ALMNAHPGDS | |
| SCHEMBL6872018 | 0.96 | ADORA2A (0.41) | ADORA2AMEN1KMT2ALMNAHPGDS | |
| SCHEMBL6870443 | 0.85 | LMNA (0.45) | ADORA2AMEN1KMT2AABL1LMNA | |
| SCHEMBL6871503 | 0.83 | ADORA2A (0.43) | ADORA2A | |
| SCHEMBL6873034 | 0.83 | ADORA2A (0.39) | ADORA2ALMNAPOLBTP53 | |
| SCHEMBL6869680 | 0.82 | ADORA2A (0.39) | ADORA2A | |
| SCHEMBL6867527 | 0.81 | ADORA2A (0.38) | ADORA2AKMT2ALMNA | |
| SCHEMBL6869624 | 0.81 | ADORA2A (0.41) | ADORA2AMEN1KMT2ALMNAPOLB | |
| SCHEMBL6868000 | 0.81 | ADORA2A (0.65) | ADORA2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |