Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869619 | 0.89 | MEN1 (0.44) | LMNAADORA2AHPGDRAB9AMEN1 | |
| SCHEMBL6873063 | 0.89 | MEN1 (0.44) | LMNAADORA2AHPGDRAB9AMEN1 | |
| SCHEMBL6863790 | 0.86 | KIT (0.46) | ADORA2AKITNPC1RAB9A | |
| SCHEMBL6869707 | 0.85 | KIT (0.44) | ADORA2AKITHPGDNPC1RAB9A | |
| SCHEMBL6869677 | 0.85 | ADORA2A (0.42) | LMNAADORA2AMEN1KMT2ATP53 | |
| SCHEMBL6863748 | 0.84 | ADORA2A (0.64) | LMNAADORA2AHPGDNPC1RAB9A | |
| SCHEMBL6872018 | 0.83 | ADORA2A (0.41) | LMNAADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL6870459 | 0.82 | ADORA2A (0.43) | LMNAADORA2AGRM1HPGDNPC1 | |
| SCHEMBL6868095 | 0.81 | KDM4E (0.53) | LMNAADORA2AHPGDNPC1RAB9A | |
| SCHEMBL6869714 | 0.81 | ADORA2A (0.43) | ADORA2AHPGDNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |