Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939731 | 0.86 | SLC6A4 (0.56) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6941934 | 0.86 | SLC6A4 (0.56) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6865381 | 0.84 | SLC6A2 (0.60) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL8686122 | 0.83 | SLC6A2 (0.59) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL150032 | 0.82 | SLC6A4 (0.73) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL8610667 | 0.80 | OPRM1 (0.42) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL7025932 | 0.78 | SLC6A4 (0.51) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL27581954 | 0.78 | SLC6A4 (0.44) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| Desmetramadol SCHEMBL57246 | 0.77 | OPRM1 (1.00) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| O-Desmethyl Tramadol SCHEMBL4396389 | 0.77 | OPRM1 (1.00) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069106-B1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0799819-B1 | 1-Dimethylaminomethyl 2-phenyl cycloalk-2-ene derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-1069106-A2 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| EP-0983994-A2 | Pharmaceutically-active dimethyl-(3-aryl-but-3-enyl)-amine compounds | Grünenthal GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |