Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 16/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867550 | 0.88 | ADORA2A (0.67) | ADORA2AHPGD | |
| SCHEMBL6873039 | 0.88 | ADORA2A (0.66) | ADORA2AALDH1A1 | |
| SCHEMBL6863742 | 0.81 | ADORA2A (0.52) | ADORA2AMAPTHPGDHSD17B10 | |
| SCHEMBL6868095 | 0.81 | KDM4E (0.53) | ADORA2ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7144637 | 0.80 | ADORA2A (0.55) | ADORA2A | |
| SCHEMBL6869305 | 0.80 | ADORA2A (0.79) | ADORA2A | |
| SCHEMBL6869838 | 0.79 | ADORA2A (0.43) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6870333 | 0.79 | ADORA2A (0.75) | ADORA2A | |
| SCHEMBL6873003 | 0.79 | ADORA2A (0.78) | ADORA2A | |
| SCHEMBL6871247 | 0.78 | ADORA2A (0.53) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |