Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868095 | 0.85 | KDM4E (0.53) | ADORA2ALMNAKDM4EHTTHSD17B10 | |
| SCHEMBL6869803 | 0.85 | ADORA2A (0.41) | ADORA2AMEN1POLBKMT2A | |
| SCHEMBL6863147 | 0.81 | CHRM4 (0.46) | KDM4EHTTMEN1RECQLKMT2A | |
| SCHEMBL6869813 | 0.80 | ADORA2A (0.44) | ADORA2AHSD17B10MEN1POLBALOX15 | |
| SCHEMBL6863099 | 0.79 | ADORA2A (0.45) | ADORA2A | |
| SCHEMBL6871623 | 0.79 | ADORA2A (0.67) | ADORA2AKDM4E | |
| SCHEMBL6873039 | 0.79 | ADORA2A (0.66) | ADORA2AALDH1A1 | |
| SCHEMBL6867550 | 0.79 | ADORA2A (0.67) | ADORA2AHPGD | |
| SCHEMBL6869733 | 0.79 | ADORA2A (0.52) | ADORA2ALMNAKDM4EHTTHSD17B10 | |
| SCHEMBL6869842 | 0.78 | PLAU (0.48) | ADORA2ALMNAKDM4EHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |