SCHEMBL6869854

SCHEMBL6869854

Cc1[nH]c2ccc(Cl)cc2c1C(=O)C(=O)Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.49
GAA P10253 2/20 0.47
CYP1A2 P05177 1/20 0.47
HPGD P15428 1/20 0.47
SIRT1 Q96EB6 3/20 0.47
CHEK1 O14757 1/20 0.46
ADRA2A P08913 1/20 0.44
ADRA2B P18089 1/20 0.44
ADRA2C P18825 1/20 0.44
HTR7 P34969 1/20 0.44
HTR2B P41595 1/20 0.44
HTR6 P50406 1/20 0.44
CSF1R P07333 1/20 0.43
ALOX5 P09917 1/20 0.43
MAP2 P11137 1/20 0.43
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2A Q12879 1/20 0.42
GRIN2B Q13224 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7681481 0.88 LMNA (0.49) LMNAGAACYP1A2HPGDSIRT1
SCHEMBL613136 0.84 LMNA (0.51) LMNAGAACYP1A2HPGDSIRT1
SCHEMBL6877031 0.83 KEAP1 (0.46) LMNAGAAHTR7HTR6
SCHEMBL31543702 0.81 ALDH1A1 (0.62) GAAHPGDHTR7HTR6
SCHEMBL5234954 0.80 NR4A2 (0.63) LMNAGAAHPGDALOX5
SCHEMBL28516701 0.79 MEN1 (0.54) LMNACYP1A2HPGDCSF1RMAP2
SCHEMBL6868509 0.79 KMT2A (0.64) LMNAGAACYP1A2
SCHEMBL8189335 0.77 LMNA (0.51) LMNAGAACYP1A2HPGDSIRT1
SCHEMBL7356882 0.77 GAA (0.49) LMNAGAACYP1A2HPGDSIRT1
SCHEMBL2202328 0.75 ALDH1A1 (0.45) LMNAGAACYP1A2HPGDSIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465610-A1 USE OF A GSK-3BETA INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR INCREASING BONE FORMATION F. HOFFMANN-LA ROCHE AG (CH) 2004-10-13 EP disclosed
WO-2003057202-A1 USE OF A GSK-3BETA INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR INCREASING BONE FORMATION F. HOFFMANN-LA ROCHE AG (CH) 2003-07-17 WO disclosed
EP-1307447-A2 3-INDOLYL-4-PHENYL-1H-PYRROLE-2,5-DIONE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3BETA F. HOFFMANN-LA ROCHE AG (CH) 2003-05-07 EP disclosed
WO-2002010158-A2 3-INDOLYL-4-PHENYL-1H-PYRROLE-2,5-DIONE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3BETA F. HOFFMANN-LA ROCHE AG (CH) 2002-02-07 WO disclosed