Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092838 | 0.74 | ACHE (0.36) | AOC3CES2CES1TAAR1ESR1 | |
| SCHEMBL28143467 | 0.74 | ALDH1A1 (0.34) | CES2CES1ESR1ACHEL3MBTL1 | |
| SCHEMBL11197865 | 0.74 | AOC3 (0.39) | AOC3CES2CES1TAAR1ESR1 | |
| SCHEMBL28268151 | 0.70 | AOC3 (0.36) | AOC3CES2CES1TAAR1ESR1 | |
| SCHEMBL28200069 | 0.70 | AOC3 (0.36) | AOC3CES2CES1TAAR1ESR1 | |
| SCHEMBL4660214 | 0.70 | AOC3 (0.45) | AOC3TAAR1ESR1ACHEL3MBTL1 | |
| SCHEMBL31469262 | 0.70 | AOC3 (0.45) | AOC3TAAR1ESR1ACHEL3MBTL1 | |
| SCHEMBL27319855 | 0.70 | NFE2L2 (0.34) | AOC3CES2CES1TAAR1ESR1 | |
| Hydrochloric Acid SCHEMBL4660143 | 0.68 | AOC3 (0.44) | AOC3TAAR1ESR1ACHEL3MBTL1 | |
| Hydrochloric Acid SCHEMBL28042395 | 0.68 | AOC3 (0.35) | AOC3CES2CES1TAAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149094-B1 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2004-04-21 | — | — | EP | disclosed |
| US-6376491-B1 | BENZOFURAN DERIVATIVES FOR TREATMENT OR PREVENTION OF MYCOSIS IN MAMMALS | BASILEA PHARMACEUTICA AG (CH) | 2002-04-23 | — | — | US | disclosed |
| EP-1149094-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | Basilea Pharmaceutica AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000037464-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2000-06-29 | — | — | WO | disclosed |