Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 10/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2165278 | 0.77 | ILK (1.00) | ILKKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL687507 | 0.76 | ILK (1.00) | ILK | |
| SCHEMBL2247189 | 0.71 | MEN1 (0.58) | ILKKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1747940 | 0.70 | MEN1 (0.59) | ILKKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL686963 | 0.69 | ILK (1.00) | ILK | |
| SCHEMBL687122 | 0.69 | ILK (0.74) | ILK | |
| SCHEMBL687454 | 0.69 | ILK (0.52) | ILKKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4807748 | 0.69 | MAPT (0.59) | ILKKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL13816496 | 0.69 | APP (0.63) | ILKKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4584286 | 0.68 | ALDH1A1 (0.56) | ILKKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | disclosed |