Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875118 | 1.00 | ALOX12 (0.57) | ALOX12MAPTACHEBACE1MCHR1 | |
| SCHEMBL6880741 | 0.84 | ACHE (0.51) | ACHEBACE1MCHR1MAPK1ADRA2A | |
| SCHEMBL6880731 | 0.84 | ACHE (0.51) | ACHEBACE1MCHR1MAPK1ADRA2A | |
| SCHEMBL6867794 | 0.83 | ACHE (0.46) | ALOX12MAPTACHEBACE1MCHR1 | |
| SCHEMBL6867785 | 0.83 | ACHE (0.46) | ALOX12MAPTACHEBACE1MCHR1 | |
| SCHEMBL6867777 | 0.82 | MEN1 (0.41) | MAPTACHEMCHR1RAB9ALMNA | |
| SCHEMBL6867769 | 0.82 | MEN1 (0.41) | MAPTACHEMCHR1RAB9ALMNA | |
| SCHEMBL4036394 | 0.80 | MCHR1 (0.66) | ALOX12MAPTMCHR1NPC1RAB9A | |
| SCHEMBL5521361 | 0.80 | MCHR1 (0.66) | ALOX12MAPTMCHR1NPC1RAB9A | |
| SCHEMBL7042080 | 0.80 | ACHE (0.48) | ACHEBACE1MCHR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |