Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867785 | 1.00 | ACHE (0.46) | ACHEBACE1MEN1KMT2ALMNA | |
| SCHEMBL6872390 | 0.89 | ACHE (0.46) | ACHEBACE1MAPK1EPHX2MCHR1 | |
| SCHEMBL6867769 | 0.88 | MEN1 (0.41) | ACHEMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6867777 | 0.88 | MEN1 (0.41) | ACHEMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6875118 | 0.83 | ALOX12 (0.57) | ACHEBACE1MEN1KMT2ALMNA | |
| SCHEMBL6875109 | 0.83 | ALOX12 (0.57) | ACHEBACE1MEN1KMT2ALMNA | |
| SCHEMBL6878118 | 0.83 | MEN1 (0.49) | ACHEBACE1MEN1KMT2ALMNA | |
| SCHEMBL6878132 | 0.83 | MEN1 (0.49) | ACHEBACE1MEN1KMT2ALMNA | |
| SCHEMBL6879418 | 0.82 | MCHR1 (0.46) | ACHEBACE1MEN1KMT2AMAPK1 | |
| SCHEMBL6879424 | 0.82 | MCHR1 (0.46) | ACHEBACE1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |