Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867777 | 1.00 | MEN1 (0.41) | MEN1KMT2ALMNAFLT3TYRO3 | |
| SCHEMBL6867785 | 0.88 | ACHE (0.46) | MEN1KMT2ALMNAMCHR1ACHE | |
| SCHEMBL6867794 | 0.88 | ACHE (0.46) | MEN1KMT2ALMNAMCHR1ACHE | |
| SCHEMBL6456622 | 0.85 | SIGMAR1 (0.48) | MCHR1ACHEALDH1A1SMN1; SMN2ADRA2A | |
| SCHEMBL6456613 | 0.85 | SIGMAR1 (0.48) | MCHR1ACHEALDH1A1SMN1; SMN2ADRA2A | |
| SCHEMBL6867944 | 0.85 | ADRA2A (0.42) | MEN1KMT2AFLT3TYRO3MERTK | |
| SCHEMBL6867978 | 0.85 | ADRA2A (0.42) | MEN1KMT2AFLT3TYRO3MERTK | |
| SCHEMBL6878132 | 0.84 | MEN1 (0.49) | MEN1KMT2ALMNAPKMMCHR1 | |
| SCHEMBL6878118 | 0.84 | MEN1 (0.49) | MEN1KMT2ALMNAPKMMCHR1 | |
| SCHEMBL6872864 | 0.83 | ALDH1A1 (0.56) | MEN1KMT2ALMNAMCHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |