Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.52 |
| ▸ | MMP12 | P39900 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875177 | 0.87 | KMT2A (0.57) | EPHX2NR1H4MMP12MEN1KMT2A | |
| SCHEMBL6871411 | 0.86 | NR1H4 (0.67) | EPHX2NR1H4MMP12MEN1KMT2A | |
| SCHEMBL6667161 | 0.86 | MMP12 (0.60) | EPHX2NR1H4MMP12CYP1A2CYP2C19 | |
| SCHEMBL6882443 | 0.86 | MMP12 (0.52) | EPHX2NR1H4MMP12MEN1KMT2A | |
| SCHEMBL6667189 | 0.80 | HTT (0.52) | MMP12MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL8338023 | 0.78 | MMP12 (0.57) | EPHX2MMP12KMT2ALMNA | |
| SCHEMBL8343486 | 0.76 | MMP12 (0.64) | EPHX2NR1H4MMP12RAB9ANPC1 | |
| SCHEMBL6881395 | 0.76 | MMP12 (0.58) | EPHX2NR1H4MMP12 | |
| SCHEMBL8343187 | 0.76 | LMNA (0.67) | NR1H4MMP12MEN1KMT2ARAB9A | |
| SCHEMBL6881932 | 0.75 | MMP12 (0.59) | EPHX2NR1H4MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | claimed |
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | EPHX2 1035/4885NR1H4 251/4885MMP12 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.