Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867978 | 1.00 | ADRA2A (0.42) | ADRA2AMCHR1ACHEMEN1KMT2A | |
| SCHEMBL6869175 | 0.85 | KDM1A (0.44) | ADRA2AMCHR1ACHEJAK3BACE1 | |
| SCHEMBL6456622 | 0.85 | SIGMAR1 (0.48) | ADRA2AMCHR1ACHEALDH1A1 | |
| SCHEMBL6456613 | 0.85 | SIGMAR1 (0.48) | ADRA2AMCHR1ACHEALDH1A1 | |
| SCHEMBL6869183 | 0.85 | KDM1A (0.44) | ADRA2AMCHR1ACHEJAK3BACE1 | |
| SCHEMBL6867769 | 0.85 | MEN1 (0.41) | ADRA2AMCHR1ACHEMEN1KMT2A | |
| SCHEMBL6867777 | 0.85 | MEN1 (0.41) | ADRA2AMCHR1ACHEMEN1KMT2A | |
| SCHEMBL6875264 | 0.83 | LMNA (0.54) | ADRA2AMCHR1KMT2AMAPK8MAPK9 | |
| SCHEMBL6878043 | 0.83 | SLC2A1 (0.43) | ADRA2AMCHR1ACHEMEN1KMT2A | |
| SCHEMBL6875616 | 0.82 | KDM1A (0.46) | ADRA2AMCHR1ACHEKMT2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |