Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875814 | 1.00 | PKM (0.54) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6877551 | 0.91 | NPC1 (0.56) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6877545 | 0.91 | NPC1 (0.56) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6875509 | 0.90 | ALDH1A1 (0.46) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6875517 | 0.90 | ALDH1A1 (0.46) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6873049 | 0.87 | ALDH1A1 (0.45) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6873057 | 0.87 | ALDH1A1 (0.45) | PKMADRA2AMCHR1KMT2AMEN1 | |
| SCHEMBL6871841 | 0.86 | SMN1; SMN2 (0.55) | ADRA2AMCHR1KMT2AMEN1NPC1 | |
| SCHEMBL6871842 | 0.86 | SMN1; SMN2 (0.55) | ADRA2AMCHR1KMT2AMEN1NPC1 | |
| SCHEMBL6879588 | 0.85 | NPC1 (0.57) | PKMADRA2AMCHR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |