Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | AGXT | P21549 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735768 | 0.79 | CLK4 (0.57) | ADRB2CLK4AOC3HDAC1HDAC8 | |
| SCHEMBL6878724 | 0.76 | ADRB2 (0.62) | ADRB2CLK4IDO1AGXT | |
| SCHEMBL6875904 | 0.73 | ADRB2 (0.53) | ADRB2CLK4AOC3HDAC1HDAC8 | |
| SCHEMBL2560488 | 0.72 | ADRB2 (0.63) | ADRB2CLK4AOC3HDAC1HDAC8 | |
| SCHEMBL444754 | 0.72 | LOXL2 (0.41) | — | |
| SCHEMBL10162103 | 0.72 | ADRB2 (0.63) | ADRB2CLK4NPC1RAB9AKMT2A | |
| SCHEMBL6854269 | 0.72 | ADRB2 (0.49) | ADRB2CLK4AOC3HDAC1HDAC8 | |
| SCHEMBL58206 | 0.72 | TSHR (0.52) | HDAC6IDO1AGXT | |
| SCHEMBL6685962 | 0.71 | CLK4 (0.64) | ADRB2CLK4AOC3DYRK1ANPC1 | |
| SCHEMBL6853976 | 0.69 | ADRB2 (0.59) | ADRB2CLK4AOC3KMT2ACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |