Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6460185 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RSLC6A4HTR1A | |
| SCHEMBL6462830 | 0.89 | ADRA2A (0.43) | MCHR1ADRA2ASLC6A4HTR1AIDO1 | |
| SCHEMBL6868965 | 0.89 | ADRA2A (0.43) | MCHR1ADRA2ASLC6A4HTR1AIDO1 | |
| SCHEMBL6457485 | 0.88 | EIF2AK2 (0.43) | SLC6A4HTR1ASIGMAR1GPR84MTNR1A | |
| SCHEMBL6877984 | 0.88 | MAPK8 (0.49) | MCHR1ADRA2ANPY5RHTR1AMAPK8 | |
| SCHEMBL6877981 | 0.88 | MAPK8 (0.49) | MCHR1ADRA2ANPY5RHTR1AMAPK8 | |
| SCHEMBL6880166 | 0.81 | MCHR1 (0.49) | MCHR1ADRA2ANPY5R | |
| SCHEMBL6464914 | 0.81 | MCHR1 (0.49) | MCHR1ADRA2ANPY5R | |
| SCHEMBL6878737 | 0.81 | MCHR1 (0.49) | MCHR1ADRA2ANPY5R | |
| SCHEMBL6456397 | 0.81 | MCHR1 (0.49) | MCHR1ADRA2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |