Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462830 | 1.00 | ADRA2A (0.43) | ADRA2AMCHR1HTR1ASLC6A4IDO1 | |
| SCHEMBL6460185 | 0.89 | MCHR1 (0.46) | ADRA2AMCHR1HTR1ASLC6A4IDO1 | |
| SCHEMBL6875983 | 0.89 | MCHR1 (0.46) | ADRA2AMCHR1HTR1ASLC6A4IDO1 | |
| SCHEMBL6875158 | 0.87 | EIF2AK2 (0.46) | HTR1ASLC6A4GPR84LMNAKMT2A | |
| SCHEMBL6875163 | 0.87 | EIF2AK2 (0.46) | HTR1ASLC6A4GPR84LMNAKMT2A | |
| SCHEMBL6875264 | 0.87 | LMNA (0.54) | ADRA2AMCHR1HTR1AOPRM1OPRL1 | |
| SCHEMBL13793703 | 0.79 | MCHR1 (0.66) | ADRA2AMCHR1HTR1AOPRM1OPRL1 | |
| SCHEMBL6874250 | 0.79 | ADRA2A (0.46) | ADRA2AMCHR1HTR1ASLC6A4IDO1 | |
| SCHEMBL6457965 | 0.79 | ADRA2A (0.46) | ADRA2AMCHR1HTR1ASLC6A4IDO1 | |
| SCHEMBL6462492 | 0.78 | MCHR1 (0.66) | ADRA2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |