Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | JUN | P05412 | 3/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877984 | 1.00 | MAPK8 (0.49) | MAPK8MAPK9MAPK10HTR1ACDK2 | |
| SCHEMBL6875264 | 0.89 | LMNA (0.54) | MAPK8MAPK9MAPK10HTR1ACDK2 | |
| SCHEMBL6460185 | 0.88 | MCHR1 (0.46) | MAPK8MAPK9MAPK10HTR1ACDK2 | |
| SCHEMBL6875983 | 0.88 | MCHR1 (0.46) | MAPK8MAPK9MAPK10HTR1ACDK2 | |
| SCHEMBL6457485 | 0.86 | EIF2AK2 (0.43) | HTR1ALMNAKMT2A | |
| SCHEMBL6462237 | 0.85 | HTT (0.52) | MAPK8MAPK9MAPK10HTR1ACDK2 | |
| SCHEMBL6460015 | 0.85 | HTT (0.52) | MAPK8MAPK9MAPK10HTR1ACDK2 | |
| SCHEMBL6868464 | 0.84 | MCHR1 (0.44) | MAPK8MAPK9MAPK10NPY5RADRA2A | |
| SCHEMBL6463054 | 0.84 | MCHR1 (0.44) | MAPK8MAPK9MAPK10NPY5RADRA2A | |
| SCHEMBL6874708 | 0.82 | MCHR1 (0.42) | MAPK8MAPK9MAPK10HTR1ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |