Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 6/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980536 | 0.88 | HTR2B (0.46) | HTR2BCYP51A1KDM5AHRH4STAT6 | |
| SCHEMBL2229951 | 0.86 | CYP51A1 (0.39) | HTR2BCYP51A1KDM5AHRH4STAT6 | |
| SCHEMBL2228283 | 0.86 | CYP51A1 (0.48) | CYP51A1HRH4STAT6AKR1C3DRD2 | |
| SCHEMBL19856859 | 0.85 | CYP51A1 (0.40) | HTR2BCYP51A1KDM5AHRH4STAT6 | |
| SCHEMBL1550050 | 0.85 | CYP51A1 (0.40) | HTR2BCYP51A1KDM5AHRH4STAT6 | |
| SCHEMBL1549976 | 0.85 | CYP51A1 (0.40) | HTR2BCYP51A1KDM5AHRH4STAT6 | |
| SCHEMBL6872132 | 0.83 | KDM5A (0.44) | HTR2BCYP51A1KDM5ADRD2 | |
| SCHEMBL2227969 | 0.82 | HRH4 (0.45) | CYP51A1KDM5AHRH4STAT6DRD2 | |
| SCHEMBL1550049 | 0.81 | DRD2 (0.37) | HTR2BCYP51A1KDM5AHRH4STAT6 | |
| SCHEMBL12552765 | 0.81 | DRD2 (0.37) | CYP51A1KDM5ASTAT6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |