Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 7/20 | 0.41 |
| ▸ | CTSK | P43235 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 6/20 | 0.40 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517777 | 0.89 | CTSS (0.48) | CTSSCTSKCTSLCTSB | |
| SCHEMBL5523231 | 0.89 | ALDH1A1 (0.56) | KDM4EALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL5518404 | 0.87 | POLB (0.52) | KDM4EALDH1A1CYP1A2POLBCTSL | |
| SCHEMBL5532239 | 0.87 | CTSS (0.46) | KDM4ECTSSCTSKALDH1A1CYP1A2 | |
| SCHEMBL6742393 | 0.82 | CTSS (0.49) | CTSSCTSKCTSLCTSBATM | |
| SCHEMBL5524114 | 0.79 | CTSL (0.56) | CTSSCTSKCTSLCTSB | |
| SCHEMBL6876870 | 0.78 | CTSS (0.47) | CTSSCTSKPOLBCTSLCTSB | |
| SCHEMBL5520661 | 0.77 | CTSS (0.46) | CTSSCTSKCTSLCTSBMEN1 | |
| SCHEMBL5521867 | 0.77 | ADRB1 (0.47) | CTSSCTSKCYP2C9CTSLCTSB | |
| SCHEMBL5527139 | 0.76 | KDM4E (0.43) | KDM4ECTSSALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1452522-A2 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2004-09-01 | — | — | EP | disclosed |