Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874339 | 0.90 | ADRA2A (0.44) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6880422 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL4034147 | 0.85 | MCHR1 (0.57) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL4034150 | 0.85 | MCHR1 (0.57) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6465515 | 0.83 | HPGD (0.51) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6465514 | 0.83 | HPGD (0.51) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6465511 | 0.83 | HPGD (0.51) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872959 | 0.82 | MCHR1 (0.40) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872955 | 0.82 | MCHR1 (0.40) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875905 | 0.81 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |