Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 2/20 | 0.41 |
| ▸ | EIF4E | P06730 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039301 | 0.90 | CDC25A (0.49) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL6879620 | 0.87 | NOTUM (0.44) | ALDH1A1KDM4ERAB9ASMN1; SMN2EIF4E | |
| SCHEMBL6881410 | 0.87 | EIF4E (0.49) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6879341 | 0.87 | EIF4E (0.45) | ALDH1A1KDM4EHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6881069 | 0.87 | CYP1A1 (0.44) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL5044423 | 0.87 | MAPT (0.44) | ALDH1A1GAAKDM4EHPGDMAPT | |
| SCHEMBL6871896 | 0.87 | NOTUM (0.43) | ALDH1A1GAAKDM4EHPGDMAPT | |
| SCHEMBL6882755 | 0.86 | CPT2 (0.47) | EIF4ENOTUMCDC25ACDC25BCDC25C | |
| SCHEMBL6872874 | 0.86 | NOTUM (0.42) | MAPTEIF4ENOTUM | |
| SCHEMBL6879641 | 0.86 | IDH1 (0.46) | ALDH1A1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | ALDH1A1 959/4885GAA 4333/4885KDM4E 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.