Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 2/20 | 0.40 |
| ▸ | CDC25B | P30305 | 2/20 | 0.40 |
| ▸ | CDC25C | P30307 | 2/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 5/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.36 |
| ▸ | ATP4B | P51164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039301 | 0.92 | CDC25A (0.49) | NOTUMCDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL6881410 | 0.91 | EIF4E (0.49) | CDC25ACDC25BCDC25CDUSP3ALDH1A1 | |
| SCHEMBL6879620 | 0.88 | NOTUM (0.44) | NOTUMCDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL6877134 | 0.87 | ALDH1A1 (0.48) | NOTUMCDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL5040235 | 0.86 | HTR2A (0.42) | CYP1A1CYP1B1CDC25ACDC25BCDC25C | |
| SCHEMBL6882755 | 0.85 | CPT2 (0.47) | NOTUMCDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL6871896 | 0.85 | NOTUM (0.43) | NOTUMCDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL6879641 | 0.84 | IDH1 (0.46) | NOTUMALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL6872874 | 0.84 | NOTUM (0.42) | NOTUMEIF4ELMNAMAPT | |
| SCHEMBL6878789 | 0.84 | NOTUM (0.42) | NOTUMCDC25ACDC25BCDC25CDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | CYP1A1 563/4885CYP1B1 459/4885NOTUM 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.